The city was conquered by the Seljuk Turks. The inhabitants of Laodicea were also resettled here in the Seljuk period.

Ibn Battuta visited the city, noting that “In it there are seven mosques for the observance of Friday prayers, and it has splendid gardens, perennial streams, and gushing springs. Most of the artisans there are Greek women, for in it are many Greeks who are subject to the Muslims and who pay dues to the sultan, including the jizyah, and other taxes.”

In the 17th century, the Turkish traveler Evliya Çelebi visited Denizli and recorded the town as follows: “The city is called by Turks as (Denizli) (which means has abundant of water sources like sea in Turkish) as there are several rivers and lakes around it. In fact it is a four-day trip from the sea. Its fortress is of square shape built on flat ground. It has no ditches. Its periphery is 470 steps long. It has four gates. These are: painters gate in North, saddle-makers gate in the East, new Mosque gate in the South, and vineyard gate in the West.

There are some fifty armed watchmen in the fortress, and they attend the shop. The main city is outside the fortress with 44 districts and 3600 houses. There are 57 small and large mosques and district masjids, 7 madrasahs, 7 children’s schools, 6 baths and 17 dervish lodges. As everybody lives in vineyards the upper classes and ordinary people do not flee from each other.”

The city lived in peace for centuries without being involved in wars in a direct manner. Following World War I during the Independence War, the Greek forces managed to come as close as Sarayköy, a small town 20 km northwest of Denizli, but did not venture into Denizli. The most widespread symbols of Denizli province are of textile industry.