In addition to intra-city transportation, Santiago also offers private bus services that connect the city to other major cities in the country.

Some of the well-known bus companies operating in the region include Dioni, Metro, Caribe Tours, Transporte Espinal, and Aetra Bus.

These companies provide reliable and efficient transportation options to residents and visitors alike, making it easier to travel between cities in the Dominican Republic.

When it comes to highways, the Autopista Juan Pablo Duarte, also known as DR-1, is a major artery that runs through the city center. This highway not only connects Santiago directly to the capital city of Santo Domingo but also serves as a vital link to other regions in the country.

Additionally, there are several minor highways that connect Santiago to popular destinations such as Puerto Plata, Samaná, and the northwestern part of the country. These well-maintained roadways provide easy access to these areas, ensuring convenient travel for both tourists and locals.