Melik Necmeddin Isa fought against Mongol King Timur in Mardin and was imprisoned in this madrasah for a while upon losing the battle.

The Sultan Isa Madrasa, draws attention even from afar with its sliced shaped domes on its eastern and western ends and a high monumental portal that coincides with its eastern side.

The building, which covers a rectangular and wide area, consists of a courtyard, mosque, tomb and various additional spaces on two floors. When you enter through the gate, a section covered with a star vault may be seen.

On the west, there is a corridor opening to the courtyard to the mosque. The upper floor consists mostly of small rooms. These are the chambers of the people who once studied in the madrasah.