The current church was built in 1869 as the Yeni Cami (“New Mosque”) and in 1925 it was converted to Christian worship. The church was declared a cathedral of the archdiocese of Crete in 2013. The church is an eclectic style square temple with a dome. The exterior of the temple is dominated by vertical elements, while at the top there is a stone-carved apse.

History
After the reconquest of Crete by the Byzantines in 961, the episcopal seat of Crete was moved from Gortyn to Chandax (later Candia, modern Heraklion), which became the capital of the island. A new metropolitan church was built in Chandax, dedicated to the apostle Titus, the first bishop of Crete.

That church was a single-aisled building. Various relics were brought to the church, among which the Holy Head of Titus and the icon of Virgin Mary Mesopanditissa. In 1210, Crete came under the control of the Venetians and a Roman Catholic archbishop was installed in the church.

It underwent some modifications, such as the opening of a circular skylight and the construction of a bell tower. This first building was destroyed before the middle of the 15th century.