It consists of two museums: the Şanlıurfa Museum and the Haleplibahçe Mosaic Museum. The Şanlıurfa Museum was originally founded in 1965 and moved to its present location in 2015.

With over 34,000 square meters of indoor space, it is the largest museum in Turkey. It has 14 exhibition halls and 33 animation areas and houses some 10,000 artifacts from the Paleolithic through Islamic times. This includes finds from Göbekli Tepe, Harran, and the areas now inundated by the Atatürk Dam.

As for the Haleplibahçe Mosaic Museum, it was built in situ on the top of where the Haleplibahçe mosaics were originally found. Among the mosaics on display here is the oldest known mosaic to depict the Amazons.