During the first half of the 20th century, the island was popular with prosperous Greeks, Jews and Armenians as a refuge from the summer heat of Istanbul. Nowadays the island is almost as solidly Turkish as any suburb of mainland Istanbul.

Historically, many residents of Büyükada were fishermen. However, by the late 2010s tourism to Büyükada swelled enormously as it became a favourite day-trip destination for visitors from greenery-starved Arab countries in particular. The surge in tourism was a major factor in bringing to an end the tradition of using phaetons as the only transport on the island in 2020.

Visitors have been writing about Büyükada since the Turkish travel writer Evliya Çelebi recorded in his Seyahatname (Book of Travels) that there were 200 Greek houses on the island in 1640 and that it was ringed with dalyan fishermen.

The island is accessible by Şehir Hatları ferries from Eminönü and Kabataş on the European side of Istanbul and from Kadıköy and Bostancı on the Asian side of the city.